American Marconi Wireless News - ISOThrive Final Phase 2 Results for MHS-1031 Announced at ACG 2026 Demonstrate Statistically Significant and Clinically Meaningful Improvement in Heartburn Frequency and Severity in NERD PPI-Partial Responders

HEALDSBURG, CA / ACCESS Newswire / October 12, 2026 / ISOThrive Inc. today announced final results from its Phase 2 trial of MHS-1031 in patients with non-erosive reflux disease (NERD) who experience an incomplete response to proton pump inhibitors (PPIs). Peter Swann, MD, Chief Medical Officer of ISOThrive, and David Johnson, MD MACG FASGE VGSF MACP, Professor of Medicine and Chief of Gastroenterology at Eastern Va Medical School/Old Dominion University, Norfolk VA, and an investigator in the study, are presenting the results at the American College of Gastroenterology (ACG) 2026 Annual Scientific Meeting today.

MHS-1031 met all primary and secondary efficacy endpoints with clinically meaningful and highly statistically significant reductions in heartburn incidence and severity.

Highly significant improvements in RESQ-eD Regurgitation scores were also observed, reflecting a potential new treatment result not observed with PPIs and PCABs.

"These final results are particularly encouraging because they demonstrate the potential to provide meaningful symptom relief for patients who continue to struggle with heartburn despite PPI treatment," said Dr. Swann. "The consistency of the findings across heartburn frequency, severity, regurgitation and overall symptom burden, both with a PPI and after PPI withdrawal, provides a strong rationale for advancing the clinical development of MHS-1031."

"Current acid-suppressive therapies do not adequately control symptoms in a substantial proportion of patients with NERD," said Dr. Johnson. "These findings support further investigation of the esophageal microbiome as a therapeutic target and highlight the potential value of addressing mechanisms of reflux disease beyond acid suppression."

Current acid-suppressive therapies leave many patients with NERD experiencing persistent symptoms, even with increased PPI doses or a switch to PCAB therapy. Emerging research suggests that imbalances in the esophageal microbiome may contribute to inflammation and heightened sensitivity to reflux. MHS-1031 is a novel glycan therapeutic designed to modulate the esophageal microbiome, potentially reducing inflammatory signaling associated with persistent heartburn and addressing an underlying disease mechanism not targeted by conventional acid-suppressive therapies.

About ISOThrive

ISOThrive Inc. is a clinical-stage biopharmaceutical company developing novel glycan therapeutics that target the microbiome to address large clinical unmet needs in gastrointestinal disease. The company is advancing MHS-1031, an investigational glycan therapeutic designed to modulate the esophageal microbiome and address mechanisms of reflux disease beyond acid suppression.

ACG Awards and Special Recognition

Presidential Poster Awards recipients are identified by blue ribbon badges. Winners are chosen by the ACG Abstract Selection Committee based on scores and merit of qualifying abstracts submitted.

MHS-1031 is an investigational product and has not been approved by the U.S. Food and Drug Administration.

Media Contact: Jack Oswald, CEO/CTO | [email protected] | 415-272-6200

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SOURCE: ISOThrive

View the original press release on ACCESS Newswire

O.Karlsson--AMWN